Revolutionary Discovery: Bacteria Modified to Combat Cancer in Mice
Cancer is a complex disease that affects millions of people worldwide, and finding a cure has been the tireless goal of the scientific community for many years. Recently, a team of scientists has made a significant breakthrough in the fight against cancer by modifying bacteria to fight cancer cells in mice. The team of researchers from the University of Pittsburgh in the United States engineered salmonella bacteria to colonize tumors and deliver anti-cancer drugs directly to them.
Modifying Bacteria to Target Cancer Cells
The team of researchers led by Hong Liu, an associate professor of microbiology and molecular genetics, used salmonella typhimurium bacteria for the study. They genetically modified the bacteria by deleting specific genes to make them safer and non-toxic.
They then added genes for chemical attraction to cancer cells, allowing the bacteria to target and colonize tumors better. The modified bacteria could penetrate and colonize tumors in mice, where they delivered their payload of anti-cancer drugs.
The Results of the Study
The team of researchers tested the effectiveness of modified bacteria by injecting them into mice with tumors, followed by a combination of chemotherapy and radiation treatment. The results showed that the use of modified bacteria increased the effectiveness of cancer treatments significantly. The mice that received modified bacteria had smaller tumors and lived longer than those who did not receive modified bacteria.
Implications of the Study
The study offers new hope for cancer patients, and the use of bacteria to deliver drugs directly to the tumors is a promising area of research. The use of modified bacteria may also reduce the risk of toxic side effects that are associated with traditional cancer treatments such as chemotherapy and radiation. The team is now conducting further studies to determine if this method can be used in humans effectively.
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The University of Pittsburgh researchers have engineered salmonella bacteria to colonize tumors and deliver anti-cancer drugs directly to them. They added genes for chemical attraction to cancer cells, allowing the bacteria to target and colonize tumors better, significantly increasing the effectiveness of cancer treatments. The use of modified bacteria may be a new hope for cancer patients and reduce the risk of toxic side effects associated with traditional cancer treatments. #HEALTH